About 3,730 km from source to mouth

Photo from Wikimedia Commons
Mississippi River
North America's great central artery/Water
The Mississippi drains about 40% of the contiguous United States, collecting water from 31 states and two Canadian provinces. Its discharge into the Gulf of Mexico is so massive it creates a visible plume of sediment stretching far out to sea. The river has shifted its course dramatically over geological time, and only an elaborate system of levees and spillways keeps it in its current channel.
Measurements
About 16,800 m³/s average discharge × 86,400 seconds per day
About 2.98 million square km -- roughly 40% of the contiguous US
At Lake Winnibigoshish in Minnesota, about 17.7 km wide
Near Algiers Point in New Orleans
About 145 million metric tons of sediment per year